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Binding sites in the mouse genome are enriched in sequences found in the peaks of especially navigable landscapes and the genetic diversity of binding sites in yeast increases with the number of sequences in a peak.
PRP contains fibrin, a cytocompatible structure that promotes cell proliferation due to the high diversity of binding sites that contains35, while SF contains HA, a glycosaminoglycan that facilitates the MSCs migration in the extracellular matrix through the interaction between HA and CD44 reCD44ors36.
This diversity of binding sites provides specificity to counter semiredundancy and was thought to be a recent evolutionary acquisition.
The low degree of sequence conservation of this region might correlate with the diversity of binding partners, not only Rho GTPases, and subcellular localization patterns described.
In contrast, RO1 forms more hydrogen bonds with HIV protease, which enhances the binding energy and is also a step toward a greater diversity of binding patterns.
Sundberg et al. [ 62] have analyzed complexes of different SAGs with T cell receptors (TCRs) and observed a diversity of binding modes backbone conformations.
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Depending on the diversity of the binding sites, the protein binding to a mixture of proteins can still exhibit specificity, as we recently showed for ECM.
The titer of juvenile hormone (JH) is determined by three factors: its rate of synthesis, its rate of degradation, and the degree to which JH is protected from degradation by binding to a diversity of JH-binding proteins.
The results of simulated tempering ligand dynamics at the protein protein interface reveals a diversity of ligand binding modes that is consistent with the structural orientation of the benzimidazole ring which closely mimics the position of the mutated W104 hot spot residue in the wild-type hGH hGHbp complex.
However, the BlockLogo figure shows a large number of different combinations and the high diversity of this binding site.
The highest diversity of ligand binding activities was shown for members of the Bet v 1 family.
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