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This current spectrum of genes for TLRs arose by multiple gene duplication and during the last 700 Mya diversified to recognize distinct MAMPs [ 29, 31- 36].
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These genes are most closely related to NR Family 1 and 4. With the available data, we cannot conclude whether these represent the descendents of ancient NRs that later diversified into recognized NR families or if these genes represent an independent radiation somewhere within the cnidarian lineage.
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