Our current findings suggest that the previously observed diversified and tissue-specific expression of elements in the HERV-W family is the result of both directed transcription (involving both the LTR and internal sequence) and leaky transcription of HERV-W elements in normal human tissues.
Biological cells and tissues have diversified behaviors, which are supported by active tissues and passive tissues.
The use of micro-fabrication and ex vivo application of engineered liver tissue has diversified the materials type used in this field to include material chosen for its applicability to fabrication route rather than biological response.
Gene expression also varied among tissues, with Picea paralogs having diversifying expression from tissue-specific to broadly expressed in most or all tissues.
In addition to these pigmentation defects and tumors of the peripheral nervous system (PNS), NF1 patients demonstrate highly diversified clinical features with multiple tissue types affected.
However, the applicability for the dissection of highly diversified protein families in complex tissues remains to be explored.
We have delineated the sequential lineage steps through which ESCs diversify into various tissues, and in so doing, developed methods to exclusively induce certain fates at the expense of others.
Nevertheless, the differential expression pattern observed across tissues for tlr22 paralogues indicates that this gene may have diversified to attain specific roles in different tissues of cod.
This functional flexibility has indeed diversified the transcriptional regulation in different tissues or cell types.
Maehara, K. Tissue-specific expression of histone H3 variants diversified after species separation.
Maehara, K. et al. Tissue-specific expression of histone H3 variants diversified after species separation.
