The structure reveals a β fold that is representative of the m02-m06 family of viral proteins, several of which are known to bind MHC-I molecules and interfere with antigen presentation, suggesting its role as a diversified immune regulation module.
Alternative promoter usage has been shown to enable diversified transcriptional regulation in different cellular conditions or development stages [10], [11], and along with alternative splicing are the primary sources of 5'UTR transcript diversity [12].
Alternative Promoter (AP) usages have been shown to enable diversified transcriptional regulation of individual gene in a context-specific (e.g., pathway, cell lineage, tissue type, and development stage et. ac).
Alternative splicing is emerging as a major molecular mechanism to extend the repertoire of functions produced by individual genes, through the expression of multiple transcripts encoding proteins with different biochemical and physical properties, and to diversify the regulation of their expression through alternative 5' and 3'UTRs.
This functional flexibility has indeed diversified the transcriptional regulation in different tissues or cell types.
Rif1 is conserved upto mammals but its function has diversified from telomere length regulation to maintenance of genome integrity.
Such a diversifying and complex regulation control might contribute to the increased frequency of differential expression observed here for AP genes.
Therefore, CNV-miRNAs indeed add a more diversifying and complex regulation control to their targets and contribute to an increased likelihood of differential expression among different tissues, cell types, developmental and disease stages.
[See Peter Renton's analysis for more.] Beyond defaults, there's the issue of not hedging by remaining diversified, changes in interest rates and regulation — the latter of which there are bound to be at some point very soon.
Indeed, highly diversified functions of plant peroxidases including regulation of H2O2 level, oxidation of various substrates, generation of ROS (coupled to oxidation of IAA, amines and SA) have been reported to date.
