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These 4 modules were completed by all bacilli except for O. iheyensis although they are categorized into one of the diversified modules (pattern C).
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Distribution of the completion ratio of the KEGG functional modules in 768 prokaryotic species varied greatly with the kind of module, and all modules primarily fell into 4 patterns (universal, restricted, diversified and non-prokaryotic modules), indicating the universal and unique nature of each module, and also the versatility of the KEGG Orthology (KO) identifiers mapped to each one.
Diversified: the modules that varies in the module completion ratio among 768 prokaryotic species, Non-prokaryotic: the modules not to be completed by any prokaryotic species.
The structure reveals a β fold that is representative of the m02-m06 family of viral proteins, several of which are known to bind MHC-I molecules and interfere with antigen presentation, suggesting its role as a diversified immune regulation module.
Configuration design is widely used in complex product development to achieve diversified products based on a set of modules.
One way to study how those modules can diversify is to deliberately disrupt one of the genes in a module, and observe how the organism and its descendants respond over many generations.
Use of the reaction module concept should be of great value when studying mechanistically diversified superfamilies [ 7, 11, 13, 14, 46, 47].
It will help us to trace how the primordial promiscuous enzymes were assembled progressively in functional modules, as the present pathways diverged from ancestral pathways to give birth to the present-day mechanistically diversified superfamilies.
It is similarly diversified.
Walsh and Ranogajec diversified.
In Africa, primates diversified.
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