In this unrooted tree the highly diversified cell-cycle kinases defined in humans, CDKs1-6, fall into a large cluster with 69% Bayesian support.
The present work diversifies cell sources in combination with silk fibroin-based tissue engineering applications.
This minimal model makes testable predictions about the structural basis for directional, discrete and diversifying cell phenotype development and thus can guide the evaluation of real gene regulatory networks that govern differentiation.
Interestingly, haemopoiesis also utilizes Notch signalling to maintain stem cell identity and to diversify cell types during lineage elaboration [50].
The deterministic parts of equations describe the mean field values of the gene expression of the development network and can not exploit bifurcations to diversify cell fates.
In invertebrates, graded activity of transcription factors has been shown to control differential gene expression and thereby diversify cell fates [ 31].
A recent elegant extension of this work shows that chromatin modification of Notch targets by the Hamlet protein further diversifies cell fate and axonal targeting in olfactory neurons (Endo et al., 2012).
Although male readers are still scarce, I imagine that as the form continues to diversify cell-phone novels will find a broader audience.
Finally, DNA damage and repair cause mutations and genome rearrangements which irreversibly diversify cells in a clonal population.
From the insect blood meal to establishment inside macrophages, Leishmania parasites are likely transferred from cell to cell, a process that involves diversified host cell lineages.
