Exact(6)
The diversification stage works as follows: 1.
The aim of the diversification stage is to help the search escape local optima.
Furthermore, the proposed model enforces an explicit diversification stage during the evolution in order to avoid local optimum.
For example, a fingerprint of the protein configuration (which includes topological information) can potentially provide a more accurate comparison between same-energy individuals so that the diversification stage would result in the replacement of meaningfully similar chromosomes.
We expect to improve the performance of the proposed model for large instances by extending the diversification stage to consider other metrics for calculating the similarity between two chromosomes.
Furthermore, an explicit diversification stage engaged periodically during the population evolution replaces redundant individuals with new genetic material (generated based on the same process used in the population initialization phase).
Similar(54)
The sole MRJP-like gene of the bumblebee, Bombus terrestris (BtRJPL), represents a pre-diversification stage of the MRJP gene evolution in bees.
The phylogenetic tree indicates a rapid radiation of CDK types near the base of the CDKA and CDKB lineage, possibly representing a CDK gene diversification phase during the early stages of eukaryotic evolution.
The first stage, diversification in habitat, occurs in the early stages of evolutionary radiations, when resource competition promotes the use of different habitats.
Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).
Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the structurally related discodermolide, synthesised by a late-stage diversification strategy and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including those known to exhibit Taxol-resistance (AsPC-1, DLD-1, PANC-1, NCI/ADR).
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