Sentence examples for diversification of receptor from inspiring English sources
The separation of these genes may thus result in diversification of receptor expression and coassembly.
Residence in a region of high mutation rate may be useful for speeding up the diversification of receptor protein sequences and improving the evolvability of the organism [ 29].
The dissimilarity between the pattern of evolution in preadapted signaling transduction machinery and active diversification of receptors provides clues on how key innovations in metazoan complexity could have evolved from pre-existing machineries.
The unique somatic diversification of receptors of the immunoglobulin family during ontogeny [ i.e., V(D J recombination] mediates a dramatic increase in the number of foreign pathogen epitopes that the adaptive immune system can remember and attack (Janeway et al. 1996; Zhu et al. 2012).
Recent work is now changing this view, as several novel mechanisms for the somatic diversification of immune receptor molecules as well as genetically based polymorphism have been discovered in invertebrates [3].
The diversification of TGFβ receptor signaling outputs through various Smad complexes also provides a mechanistic basis for the opposing roles of TGFβ pathway activation in oncogenesis.
It has been hypothesized that transposable elements play a major role in the expansion and diversification of transmembrane receptor kinase-type disease resistance Xa21 gene family [ 9].
This study suggests that the majority of diversification of this receptor family occurred after the divergence of urochordates and vertebrates approximately 794 million years ago (MYA), but before the divergence of ray-finned from lobe-finned fishes around 476 MYA.
Limited proteolysis of such peptides by dipeptidyl peptidase (DPP) IV and/or structural homolog (DASH -related molecules may leaDASH -relatedntitative and, due to the diversification of their receptor preference, qualitative changes to their signaling potentials [ 2, 3].
This will provide information on the evolution and diversification of this receptor family in this biodiverse group of insects and, in a context of plant protection, ORs appear as good targets for the design of molecules capable to interfere with the ligand and thus the receptor response and the associated insect behaviour.
In other teleost species, the functions of kita and csf1ra are less well understood; comparative studies including interspecies hybrids suggest some functional diversification of both receptor tyrosine kinases even within the Danio genus (Quigley et al. 2005; Parichy 2006; Mills et al. 2007).
