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Diversification of kinase cascades may provide a mechanism for eukaryotes to evolve new developmental pathways or adapt to new environments (Bhattacharyya et al. 2006).
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This diversity in catalytic and non-catalytic domains explains the functional diversification of kinases within the eukaryotic kingdom.
It has been hypothesized that transposable elements play a major role in the expansion and diversification of transmembrane receptor kinase-type disease resistance Xa21 gene family [ 9].
In this study we examined the diversification of the GSK3/SHAGGY-like kinase genes in plants.
In other teleost species, the functions of kita and csf1ra are less well understood; comparative studies including interspecies hybrids suggest some functional diversification of both receptor tyrosine kinases even within the Danio genus (Quigley et al. 2005; Parichy 2006; Mills et al. 2007).
Moreover, we provide the first direct evolutionary link between LRR proteins and FGFRs, thus offering a novel molecular perspective for the evolutionary origins and diversification of FGFRs and LRR tyrosine kinase receptors.
Taken together, our structural and phylogenetic analyses indicate that plant GSK3/shaggy-like kinases were established prior to, or at least early in, the diversification of green plants and that the common ancestor of seed plants already had a diverse tool kit of GSK3/shaggy-like kinase genes that could be used for various signaling-related processes.
Since receptor kinases have roles in pathogen defense, self-incompatibility and various developmental processes [ 63], functional diversification of this gene family allows rapid adaptations to specific environmental conditions.
We need more diversification of funding".
There is a lack of diversification of staff.
We will have better liquidity and diversification of strategies".
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