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Alternative splicing is an important mechanism to increase proteomic diversity [ 6] which produces diverse transcripts and hence potentially diverse protein products from the same gene locus which eventually add significant complexity to the genome.
These include cytokines, chemokines, growth factors, and a repertoire of functionally diverse transcripts that have a transient response nature (13).
Recent experimental and computational studies have provided overwhelming evidence for a plethora of diverse transcripts that are unrelated to protein-coding genes.
We chose to sequence the brain and liver transcriptomes to access a large number of diverse transcripts, as these are highly complex organs with complex transcriptomes.
40 The four researchers independently constructed a thematic index by reading a sample of six information rich and diverse transcripts of antenatal and first postnatal interviews and then reached consensus through discussion.
We show that Set1 coordinates with the class II HDAC Clr3 to mediate the assembly of H3K9me-associated heterochromatin and genome-wide repression of diverse transcripts, including Tf2 retrotransposons, noncoding RNAs, and developmental and stress-response genes.
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This may be indicative of a small proportion of highly abundant transcripts from an otherwise highly diverse transcript pool, which may be higher in the digestive gland and gill due to their more active role in homeostatic mechanisms responding to food and the environment, when compared with the foot or mantle.
In this work we potentially identify such isoforms with diverse transcript expression profiles using the TS score.
This strategy recovered an interesting picture showing 31 functionally diverse transcript regulatory responses, many of which are unique to the CCM+DHA combination.
ENSEMBL makes available substantial and diverse transcript information, including the CCDS [ 13, 41], Human and Vertebrate Analysis and Annotation (HAVANA) [ 42], Vertebrate Genome Annotation (Vega) [ 43], ENCODE data [ 12] and the GENCODE gene and transcript sets [ 15].
A significant correlation between accessions containing high and low seed weight-specific haplotypes with their diverse transcript expression during seed development and varied seed weight characteristics was evident (Fig. 3D).
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