Given the role of NAADP in the generation of Ca2+ oscillations in diverse systems including cardiac arrhythmia, we reasoned that NAADP signalling may also play a role in the generation of reperfusion-induced Ca2+ oscillations that lead to lethal injury.
This has been observed in a number of diverse systems, including Drosophila socket cells (Miller et al., 2009), mouse erythroid progenitors (Wontakal et al., 2012) and zebrafish cardiomyocytes (Simoes et al., 2011), and we show here that this dual requirement is also essential for Drosophila myogenesis.
In addition, the generality of the solid-phase synthetic methodology should facilitate the construction of other sulfopeptide and sulfoprotein libraries to interrogate the importance of Tyr sulfate modifications in a number of diverse systems, including chemokine-chemokine receptor interactions (e.g. CCR5/RANTES), decoy receptors, and complement proteins, in the future.
The PB, which is divided into several lateral (LPB) and medial (MPB) subnuclei and also includes the ventrolateral Kölliker-Fuse subnucleus (KF) [20], plays diverse roles in various systems, including the respiratory, nociceptive and vestibular systems [21] [23].
We understand the reviewers' concern that it is difficult to reconcile the previously observed roles for MELK in diverse proliferating systems, including Xenopus oocytes, C. elegans and various proliferating progenitor populations in the mouse, with our findings.
The proposed selectivity of MELK for basal breast cancer cells is difficult to reconcile with an essential role for MELK in diverse proliferation systems, including Xenopus oocytes, C. elegans and various proliferating progenitor populations in the mouse (Hebbard et al. Cancer Research 2010 70 8863 and references therein).
We further demonstrate that this proxy-CRISPR strategy is applicable to diverse CRISPR Cas systems, including type II-C Cas9 and type V Cpf1 systems, and can facilitate precise gene editing even between identical genomic sites within the same genome.
From these initial plant antioxidant response investigations, a model has been proposed in which the proline-linked pentose phosphate pathway is critical for modulating protective antioxidant response pathways in diverse biological systems, including humans.
This community structure or network modularity has been identified in diverse network systems, including social [18], [19], scientific collaboration [20], metabolic [21], and molecular interaction networks [22] [24].
These domains have been shown to be potent trancription activators, used in diverse biological systems including yeast S. cerevisiae [45], [46].
HGPS affects diverse body systems including skeleton, body fat, skin, hair and the cardiovascular system.
