Our numerical evaluation shows that SSA outperforms Sobol sampling (QS) for polynomial and kriging surrogates on a diverse test bed of 13 functions.
In this paper, we show that peptide complements (or surrogates) derived from highly diverse random phage display libraries can be used for the identification of the expected natural biological partners for protein and non-protein targets.
Diversity is, instead, diverse.
These Vanguard trials served to increase safety and surrogate marker data in diverse patient cohorts, increase clinical experience with the study medication, and identify the optimal dose of medication for the phase III trial.
However, surrogates are not often evaluated under diverse ecological conditions, and this hinders the identification of spatial and temporal boundaries of a surrogate's relationship with its biodiversity metric, including whether a surrogate can predict biodiversity responses to environmental change.
While our libraries are large and diverse, it is probable that identification of a surrogate peptide with partner information is a rare event.
I'm reminded of a very moving event at the largely conservative Miami University of Ohio several weeks back; Ranked as the 4th least diverse school in the nation by the Princeton Review, our surrogate rally drew 500 students – a large number of whom showed up with handmade "Obama '08" signs.
This task is further complicated by the diverse nature of the hydrocarbons commonly considered as potential surrogate components, since they typically result in large detailed reaction schemes.
Procurement of effector/target tissues (e.g. adipose/breast) to investigate the validity of salivary pII methylation as a risk surrogate in a statistically robust manner in more diverse pediatric populations is precluded by ethical, logistical, and economic considerations.
In the original article, the presence of a more or less diverse set of neutralizing antibody-resistant variants was used as a surrogate for overall genetic diversity that could not be measured by classic sequencing.
From a conservation viewpoint, our results indicate that we should protect woodlots with diverse habitats priorly and refrain from using breeding birds and wintering species as surrogates for each other in developing conservation planning.
