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Such similarities suggest that the model proposed here for TAS2R16 function may be broadly applicable across the TAS2R family, all of which face similar challenges in recognizing diverse structural features while maintaining specificity.
Our data suggest a model in which hydrophobic residues on TM3 and TM7 form a broad ligand-binding pocket that can accommodate the diverse structural features of β-glycoside ligands while still achieving high specificity.
Clay endows B horizons with an array of diverse structural features (blocks, columns, and prisms) formed from small clay particles that can be linked together in various configurations as the horizon evolves.
This method demonstrated consistent performance with arene ene and arene yne substrates of diverse structural features, including propargyl ethers, allyl thioethers, and propargyl thioethers resulting in 6-endo products.
These assays are often carried out using multiple drug compounds with chemically diverse structural features, often in a 96 well-plate format for maximum time-efficiency, and are supported using rapid liquid chromatographic (LC) sample introduction with a tandem mass spectrometry (MS/MS) selected reaction monitoring (SRM) endpoint, taking around 6.5 h per plate.
Our measurements are consistent with emerging concepts about the structure of old-growth forests, where a high degree of complexity is generated by diverse structural features.
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BASs were successfully extracted from chemical compounds exhibiting a diverse array of structural features.
Recently, ribosomal profiling in yeast provided strong evidence for translation of uORFs in vivo and confirmed changing translation rates of the uORFs and the MCS of GCN4 in response to altered nutritional conditions 20. uORFs are extremely diverse in both structural features and regulatory functions.
Acting together, these cause diverse geomorphological features.
Nucleoside natural products are a large family of microbial secondary metabolites with diverse bioactivities and unusual structural features (Isono, 1988; Niu and Tan, 2015; Chen et al., 2016).
It is worth remembering that members of the CLC family, while functionally diverse, do share many common structural features and one does usually expect closely related proteins to behave in a similar manner.
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