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Namely, they are diverse splice variants of two closely related paralogues of fish maturation inducing-steroid receptors; they demonstrate an olfactory system specific profile of expression in fish; and they are predicted to bind Gαi, which is known to mediate the progestin olfactory response in goldfish.
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Diverse splicing variants of RAGE have been found in many tissues and the proportion seems to differ between individuals [ 6- 8].
The diverse patterns of expression and evidence of splice variants indicates that the family is rapidly evolving and suggests that the different genes have distinct functions.
Our current survey enabled us to recognize many important kinase splice variants which might be involved in diverse signal transduction pathways and have different modes of regulation.
In considering possible functional roles of these splice variants, we should note that GABAB receptors provide diverse neuronal signaling through G proteins and may have additional functions as they form complexes with other proteins [29].
This diversity is further increased by the existence of splice variants.
Although most of these splice variants have unknown functions, AS allows generation of functionally diverse NB-LRR proteins, providing a raft of conceptual links to immunity that are likely to be explored.
Natural polymorphisms and alternative splice variants may also contribute to their pharmacological diversity.
Different splice variants of caspases-8 mRNA were identified leading to the production of diverse C8 isoforms [ 28].
Importantly, since different splice variants of a given gene can have different or even antagonistic effects on diverse cellular functions, including apoptosis, proliferation, differentiation, angiogenesis and cell motility, a change in the splice variant ratio may actively contribute to tumour progression.
'macroH2A' or 'mH2A' describes a well-delimited clade of proteins containing the 'macro-domain', which sets these proteins apart from other H2A variants [ 35]. macroH2A is found in diverse animal phyla, including such basal lineages as cnidarians and placozoans [ 44], with subtypes and splice variants in vertebrates [ 29].
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