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The specific amino acid types involved in these contacts, however, are not necessarily conserved between subfamilies of GPCRs, indicating that the same protein architecture can be supported by a diverse set of interactions.
If a gene has large variance in epistatic fitness effects, then it participates in a larger and more diverse set of interactions across the genome.
There is a diverse set of interactions involving combinations of BIND interactor types (protein, RNA, DNA, gene, small molecule, complex, photon, and unidentified interactors), all of which were translated.
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However, these families contain many members and are known to have a diverse set of interaction partners and therefore functional experiments are needed to specifically test the interaction of the paralogs analyzed in this study.
At high concentrations guanidinium is a protein denaturant, but at low concentrations its trigonal-planar structure promotes a diverse set of protein interactions: it forms ion pairs with negatively charged residues and cation-π interactions with aromatic residues, is a hydrogen-bond donor, can mimic and displace the arginine side chain, and also disrupt hydrophobic interfaces [ 53, 54].
In addition, the GO analysis indicates that loss of Ess1 activity has broad consequences in the cell resulting in a functionally diverse set of genetic interactions.
The functional core of these molecules is stabilized by a diverse set of tertiary interaction motifs that often bring together distant regions of conserved nucleotides.
Polymorphic genes between populations were compared with a set of differentially expressed genes extracted from a diverse set of gene-environment interaction studies in C. elegans.
To mediate these various functions, Pellinos interact with a diverse set of substrates, and these interactions must be regulated.
Furthermore, it is likely that cross-reactive immune responses are due to a diverse set of TCR-peptide-MHC interactions.
Disparity in size and metabolic rate among species within an ecological setting may select for particular sets of adaptations creating a diverse set of sensory systems and interactions.
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