MinVar was designed to be compatible with a diverse range of sequencing platforms and allows the detection of DRMs and insertions/deletions from deep sequencing data without the need to perform additional bioinformatics analysis, a prerequisite to a widespread implementation of HIV-1 genotyping using deep sequencing in routine diagnostic settings.
The approach we have developed facilitates comparative and functional genomics studies and may be applied to improve the annotations of a diverse range of newly sequenced genomes.
We expect this type of analysis will quickly expand into a diverse range of organisms as sequencing technologies rapidly improve.
Furthermore, on the basis of a diverse range of E. coli, genome sequences of EDL933 and Sakai, 2 well-described strains of STEC O157, are ≈35 SNPs apart.
We collated data from the literature and from this study for genetic screens in which mutants were selected for a diverse range of phenotypes and where sequence data were reported or the exact mutation associated with the selected phenotype could be inferred (Table 1).
To broadly identify C2H2 zinc finger and KLF/SP proteins associated with a diverse range of Eukaryote lineages, publicly available sequenced genomes listed in table 1 were comprehensively searched including 26 metazoans, 4 unicellular holozoans, 7 holomycotans, 1 apusozoan, 4 amoebozoans, and 6 bikonts.
A diverse range of methods have been used for sequencing the whole mitochondrial genome of over fifty different species currently deposited at NCBI Organelle Genome Resources.
To determine if KAP-β diversity was similarly established early in eukaryotic evolution or if it was subsequently layered onto a conserved NPC, we chose to identify KAP-β sequences in a diverse range of eukaryotes and to investigate their evolutionary history.
Structure-specific 5′-nucleases form a superfamily of evolutionarily conserved phosphodiesterases that catalyse a precise incision of a diverse range of DNA and RNA substrates in a sequence-independent manner.
Mannosidases catalyze the hydrolysis of a diverse range of polysaccharides and glycoconjugates, and the various sequence-based mannosidase families have evolved ingenious strategies to overcome the stereoelectronic challenges of mannoside chemistry.
