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Proteins sharing the BRICHOS motif are dissimilar, and associate with a diverse range of phenotypes, varying from dementia to cancer and respiratory distress.
High genetic variation will mirror a diverse range of phenotypes, allowing populations to respond and adapt to changing environments and escape extinction [ 12].
These mutants exhibit a diverse range of phenotypes, including dominant and recessive alleles and minor, major, intermediate, and mosaic yellow foliage types.
The neural crest hypothesis posits that mild neural crest deficits during embryonic development can drive the diverse range of phenotypes affected by the domestication syndrome.
We collated data from the literature and from this study for genetic screens in which mutants were selected for a diverse range of phenotypes and where sequence data were reported or the exact mutation associated with the selected phenotype could be inferred (Table 1).
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This set of SNP markers represents a useful tool for genetic studies in An. funestus, and will be useful in identifying candidate genes that affect diverse ranges of phenotypes that impact on vector control, such as resistance insecticide, mosquito behavior and vector competence.
In some cases, mosaicism does not have any phenotypic consequences and in others exhibits a diverse range of clinical phenotypes depending on the fraction of mosaicism within a given tissue.
Mitochondrial tRNA point mutations are associated with a diverse range of clinical phenotypes that show only a limited correlation with genotype, and this considerable heterogeneity greatly complicates the diagnosis of mitochondrial disease.
Mt-tRNA point mutations have been associated with a diverse range of clinical phenotypes including epilepsy, deafness, diabetes, ophthalmoparesis, myopathy, cardiomyopathy, and encephalopathy [Florentz et al., 2003; Yarham et al., 2010].
Here, we describe the identification of nine novel mt-tRNA variants in nine families, in which the probands presented with a diverse range of clinical phenotypes including mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes, isolated progressive external ophthalmoplegia, epilepsy, deafness and diabetes.
Knockdown of Smed-meis-like through RNAi produced a diverse range of anterior regeneration phenotypes, which can be explained by a different penetrance.
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