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This may facilitate the role of αS as a hub protein, as a larger surface area allows for a diverse range of binding partners.
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This superfamily includes a diverse range of carbohydrate-binding domains and glycosyl hydrolase enzymes that share a common structural fold (see Pfam clan CL0004) [ 36- 38].
Also discovered was the lack of an adaptive immune system, and instead the possession of a large innate immune system that contained a diverse range of pathogen-binding motifs [ 8].
Similarly, PTB is also known to interact with mRNAs that encode proteins with a diverse range of functions and some of its binding partners have been identified.
The understanding of how small molecules can modulate the function of this important class of receptors by binding to a diverse range of pockets on and inside the proteins has had a profound impact on the structure-based drug design (SBDD) of new classes of therapeutic agents.
The profile of Δ Tm values measured for a protein in the presence of a sufficiently diverse range of inhibitors is characteristic of the inhibitor binding properties of that protein and therefore represents a fingerprint of the physicochemical properties of the active site.
We were unable to identify a group of food-allergic people with markedly different outcomes, however previous work has identified that those with asthma, previous severe reaction, IgE binding to a diverse range of epitopes, deficient platelet-activating factor acetyl-hydrolase or serum angiotensin-converting enzyme may have more severe food-allergic reactions [ 28– 30].
Naturally evolved binding sites, as well as unnatural amino acids and cofactors can bind a diverse range of metals, including non-biological transition elements.
These multiple binding sites underline the exceptional ability of HSA to act as a major depot and transport protein which is capable of binding, transporting and delivering an extraordinarily diverse range of endogenous and exogenous compounds in the bloodstream to their target organs [11].
The 1 is evaluated for their sensor activities in a diverse range of solvents and it has shown the selective binding affinity for Cs+.
Ubiquitin binding proteins, with their diverse range of UBDs, have emerged as key regulators of NF-κB signalling.
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