The SPI concept allows a quick and reliable evaluation of very diverse processes according to their environmental impact from a sustainable development point of view [Krotscheck C. How to measure sustainability? Comparison of flow based (mass and/or energy) highly aggregated indicators for eco-compatibility. EnvironMetrics, 1997; 8: 661997
However, precisely how SIRT1 integrates such diverse processes remains to be elucidated.
However, the general applicability of focusing on predominantly expressed or highly differentially expressed genes involved in diverse processes remains to be determined.
However, if a protein binds promiscuously to many non-functional partners, variable expression of that protein may be extremely disruptive to diverse processes, also leading to a negative correlation, in this case between the number of false positive PPIs and noise.
These findings expand our understanding of the mechanisms of substrate selection as well as the diverse cellular processes to which γ-secretase contributes.
14-3-3's are a family of conserved proteins that control many diverse processes by binding to specific phosphorylated sites on target proteins to induce changes in the target conformation or to change the target's interactions with other proteins [ 86].
They have been known to contribute to diverse processes that include cellular adhesion, signal transduction, and cell-cycle regulation[3].
The MAPK cascade transduces a broad range of extracellular stress and physiological signals, and it mediates cellular responses to diverse processes from cell proliferation and differentiation to inflammation [ 29– 31].
The presence in archaea, eubacteria and animals of coenzyme B12 and coenzyme B12-dependent enzymes seems to indicate that the conservation of these functions is important to diverse processes and this principle can also be applied to fungi.
