Furthermore, discovery of VDR expression in diverse normal human tissues including B and T lymphocytes, the hair follicle, muscle, adipose tissue, bone marrow and in cancer cells has widened the perceived scope of the vitamin D endocrine system, beyond bone homeostasis [7].
In a sharp contrast, expression of GIG47 was generally low in diverse human normal tissues.
Still, transcriptome-wide approaches will be important to broadly characterize the specific splicing alterations mediated by these proteins across diverse normal and malignant tissues.
The goal of the U.S. project will be to comprehensively map methylation and histone modifications —the two main classes of epigenetic modifications in a diverse set of normal tissues.
One of these factors is the pleiotropic cytokine IL-6, a cytokine mediating diverse biological functions in normal tissues and of particular importance in the promotion of myeloma cell expansion and survival.
The diverse expressions of the c-kit in the normal tissues result in the diverse expressions of the c-kit in the tumour tissue originated from such normal tissues (Matsuda et al, 1993; Lammie et al, 1994; Gibson and Cooper, 2002).
To further determine possible ET-specific immunogenic peptides, we utilised high-density DNA microarrays for the identification of ET-specific gene expression profiles in comparison with 133 normal tissues of diverse origin (normal body atlas, NBA) and identified 37 genes that were highly upregulated or specifically expressed in ET (Staege et al, 2004).
Using stringent criteria, we identified differentially methylated CpG sites by comparing the set of myoblasts plus myotubes (MbMt) with many diverse nonmuscle cell cultures derived from normal tissues [ 11].
Once these approaches are extended to diverse tissues through projects such as GTEx, and eventually to comparisons of diseased and normal tissues, eQTLs are set to become a core component of personalized medicine.
