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RAS protein family members (KRAS4A, KRAS4B, HRAS and NRAS) function as GDP GTP-regulated on-off switches, which reGDP GTP-regulatedc-nuclear signaling networks ruling diverse normal cellular proceswitches
The PI3K pathway, a central regulator of diverse normal cellular functions, is very often subverted during neoplastic transformation and contributes to several hallmarks of cancer that result in a competitive advantage for cancer cells [ 4- 6].
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Owing to their involvement in many regulatory processes, to their abundance, and to their diverse functions, RNAs play important roles in both normal cellular processes and diseases.
The tumor suppressor p53 is one of the most studied and most important regulators of multiple signaling pathways, including normal cellular processes and those triggered by diverse cellular stresses.
Because of the fundamental importance of cellular bioenergetics control in normal cellular physiology and pathophysiology, as well as the role of T-cell activation in diverse human pathologies, identification of this early process has broad implications.
Epigenetic homeostasis is vital for cells to maintain normal cellular functions.
Epithelial cells from the ducts of mammary glands are always among the normal cellular population3.
To maintain normal cellular proliferation, regulation of polyamine synthesis is imposed by Antizyme1 (Antizyme1
Misfolded proteins can be toxic and interfere with normal cellular functions, particularly during proteotoxic stress.
v-Myb is a doubly truncated form of its normal cellular counterpart, c-Myb.
RNA aggregation may also play a role in normal cellular function.
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