Sentence examples for diverse mutations in from inspiring English sources

Diverse mutations in the cytomegalovirus (CMV) DNA polymerase (pol) gene confer resistance to one or more of the antiviral drugs ganciclovir, foscarnet or cidofovir.

That is, the aforementioned diverse mutations in signaling pathways and networks would ultimately impact the expression and activity of metabolic enzymes, thereby enabling tumor cells to adopt specific bioenergetic features fit for their unique environment.

Although mutations are found only in several metabolic enzymes in tumors, diverse mutations in signaling pathways and networks can cause changes in the expression and activity of metabolic enzymes, which likely enable tumor cells to gain their bioenergetic versatility.

About 150 diverse mutations in SLC26A4, predominantly missense, have been reported in Pendred syndrome (8).

Because of the large numbers of diverse mutations in the splicing machinery, larger studies will be needed to fully evaluate the impact of these mutations in splicing.

The authors probed distinct pathological mechanisms underlying the disease using iPSCs derived from five patients carrying diverse mutations (in TERT, TCAB1 and DKC1), and found that the extent of the defects observed in the iPSCs correlated with clinical disease severity.

In this study, we found that diverse mutations occurred in the Ha loci of bread wheat, in the form of large deletions including entire or partial Pina-D1 coding region, and caused the PINA-null allele.

Genome sequencing of the mutants and functional analysis revealed diverse mutations implicated in resistance to pneumophages.

This study shows that diverse mutations are present in the gene of CYP102A1.

A potential limitation of these studies is, however, that they do not address in a mechanistic way how the diverse mutations and genomic alterations observed in tumor cells, either singly or in combination, contribute to the capacity of these cells to alter their microenvironment.

Importantly, such an approach may present a more economically viable solution compared with the current strategy of targeting diverse driver mutations in molecularly heterogeneous tumours.