Accordingly, the role for the pre-TCR/TCR was studied in diverse mouse models, where leukemogenesis was provoked by abnormalities in different signaling pathways.
For example, diverse mouse models reproduce the reduced levels of biogenic amines and brain-derived neurotrophic factor (BDNF) that are found in the brains of RTT patients (Wang et al., 2006; Deng et al., 2007; Li et al., 2012; Chang et al., 2006).
RETINOBASE has been developed to store, analyse, visualize and compare retinal-related data in order to provide insights into retinal gene expression in various mouse models and other organisms under diverse conditions.
The elucidation of the mutations underlying diverse rodent mouse models (monogenic and one transgenic) led to the identification of most of the currently known monogenic forms of obesity in humans [ 43].
Gross motor dysfunction and shortened lifespan are common features of diverse RTT mouse models on different genetic backgrounds and broadly recapitulate the clinical presentation in individuals with RTT (Table 2; supplementary material Table S3).
Diverse genetic mouse models, ranging from complete loss-of-function to reduced or enhanced expression, have been generated to study consequences of Mecp2 mutations (Chen et al, 2001; Guy et��al, 2001; Shahbazian et al, 2002; Collins et al, 2004; Moretti et al, 2005; Samaco et al, 2008; Bodda et al, 2013).
Finally, dogs are more genetically diverse than mouse model systems and share more genetic homology with humans than mice [ 8].
The establishment of a mouse model is of great importance, as the availability of diverse immune-deficient mouse models could deliver more insight into immunological processes of radiation nephropathy in prospective studies.
Hence, to enhance treatment efficacy and minimize drug resistance, the HER2-directed CAR approach has been developed and validated in diverse tumor-bearing mouse models, including those of osteosarcoma (Rainusso et al., 2012), breast cancer (Sun et al., 2014), renal cancer (Schonfeld et al., 2015), and glioblastoma (Zhang et al., 2016).
The authors demonstrate that the testing apparatus can be used to track the onset and progression of motor function deficits in diverse mouse neurological disease models.
To elucidate the role of unique NOS isoforms in regulating these diverse biological processes, mouse models of NOS deficiency have been generated.
