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Our study revealed diverse molecular changes beneath convergence to a simple phenotype.
It is also becoming clear that diverse molecular changes in cancers might actually be consistent in some essential cellular functions (hallmarks) whose alterations might collectively dictate malignant growth for almost all human cancers [ 23, 24].
Also, it is very likely that the small samples typically used in current studies of these areas might reflect the wide and diverse molecular changes in a complex disease only partially.
To circumvent the difficulty of finding consistent signatures themselves, we could use some biological pathways commonly affected by diverse molecular changes as modular signatures to build robust diagnostic classifiers [ 58].
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As for different cultivars of the same species with contrasting responses to chilling stress, their comprehensive comparative studies reveal relatively similar initial transcriptional responses and more diverse downstream molecular changes.
In general, taking into account the diverse but correlated molecular changes in a complex disease such as a cancer, our approach provides a framework for explaining the reproducibility of biological findings at the systems biology level.
Germ cell tumors also have diverse molecular markers with cytogenetic changes correllating with age of patient rather than type of germ cell tumor.
Our analyses provide a better understanding of how preprocessed microarray results reflect RNA levels in diverse biological samples, translating microarray expression value differences into molecular changes between samples, and highlighting tissue-specific noise properties.
Diverse microarray and sequencing technologies have been widely used to characterise the molecular changes in malignant epithelial cells in breast cancers.
Nucleotide fixation mediated by artificial selection affected diverse molecular functions and biological reactions that associated with soybean morphological and physiological changes.
The molecular changes compared with other avian genomes reflect both shared and diverse adaptations of the two penguin species to the Antarctic environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com