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The data supporting this model were obtained in diverse model systems, using ectopic telomere length modulation or TERRA regulation.
The methods presented in this communication should be of interest to many investigators working in diverse model systems.
A dominant pattern observed in studies of diverse model systems, ranging from yeast to mammals, is that secreted proteins evolve faster than intracellular proteins [ 7– 11].
The relationships between PcG complexes and cell proliferation in different developmental contexts are important and far from clear, thus further investigations using diverse model systems and approaches are necessary.
In 2007, a licensing complex, also called the Mis18 complex, consisting of KNL-2 (M18BP1, hereafter referred to as KNL-2) and its partners Mis18α/β was shown to be required for CENP-A localization to centromeres in diverse model systems (Fujita et al. 2007 ; Maddox et al. 2007 ).
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Our results highlight the value of QTL mapping plus candidate gene expression analysis in a genetically diverse model system for telomere research.
As exemplified by the diverse animal model systems and biological processes presented in this Special Issue of Gut Microbes, the study of gut microbial communities is a vibrant and highly interdisciplinary field that holds great potential for identifying new ways to promote health in humans and other animals.
For example, we did not anticipate that our search would retrieve data on such diverse nonmammalian model systems (such as zebrafish and chickens), and during the analysis, we had to interpret the heterogeneity and relevance of these data to human health.
Finally, dogs are more genetically diverse than mouse model systems and share more genetic homology with humans than mice [ 8].
Using a diverse range of model systems, from cultured cells on two-dimensional surfaces to intravital examination of xenografts, apparently distinct phenotypic processes have been described, including lamellipodial migration in 2D, and mesenchymal, amoeboid and lobopodial migration in 3D.
Resting stage differentiation in prokaryotes is diverse and in some model systems is known to be regulated by complex and hierarchical signal transduction pathways [ 4].
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