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To the best of our knowledge, this is the first study demonstrating the diverse mode of action of celecoxib on human breast cancer cells, which may be dependent upon the cells' invasive properties and levels of COX-2 expression.
The findings described in the present paper provide important new insights into the regulation of WNK kinases by CRL3KLHL3 and, moreover, shed light on the very diverse mode of interactions between substrates and their E3 ligases.
Due to their diverse mode of acting on gene expressions, different functional categories might have different such proxy measures, e.g. free energy for the micro RNAs and deleteriousness score for protein function variants (Section 1 in Supplementary Data for more details).
Deciphering whether E75 and UNF heterodimerize or bind to adjacent sequences, how they cooperate with CLK/CYC, and whether any ligand is involved in their transcriptional regulation will yield new insights into the diverse mode of nuclear receptor crosstalk and their critical roles in circadian biology.
Our analysis suggest diverse mode of the regulation of expression of miRNA genes and the processing of their miRNA precursors that could be important to coordinate with mRNA target cleavage and on which we know very little in rice and even in other plants.
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This finding is in accordance with toxicity experiments conducted in algae with mixtures of herbicides from one homogenous mode-of-action group such as chloroacetanilide [30] or phenylurea [31] and from diverse mode-of-action groups [32].
Protozoans exhibit diverse modes of locomotion across the various groups, but the modes of locomotion can be broadly divided into flagellar, ciliary, and amoeboid movement.
As John Wippel puts it, the "diverse modes of predication correspond to and reflect diverse ways in which being itself is realized, or what [Thomas] calls diverse modes of being (modi essendi).
These diverse modes of application include seed treatment, soil/foliar application, or through workable combination of different methods.
We propose the diverse modes of NLC elongation might be the key determinants shaping the plasticity of EBOV virions.
For example, silver nanoparticles (AgNPs) display diverse modes of inhibitory action against various pathogens such as fungi and bacterial species (Yamanaka et∼al. 2005; Lamsal et∼al. 2011).
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