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To perform these "scaffold-hoppings" for individual problems and targets, a plethora of different similarity methods based on diverse techniques were published in the last years.
For large and diverse data sets, simple QSAR methods based on linear and additive models can no longer be applied.
Radivojac et al. (2013) concluded that simple sequence analysis methods such as BLAST perform poorly, while more sophisticated methods based on integrating diverse data types are a substantial boon.
Our results are consistent with several recent computational methods based on the ensemble of structures, such as CC/PBSA, in which using the Concoord algorithm diverse structures are sampled to predict the stability or binding affinity change upon mutations [23].
The best scores of both indices should allow to identify the more diverse PCGs in a approach complementary to the usual method based on evolutionary distances among orthologous sequences (e.g. [ 8]).
Second, we developed DFGmodel, a method based on homology modeling that utilizes a diverse set of DFG-out template structures to generate kinase models in the inactive, DFG-out conformation.
In this paper, a fuzzy adaptive nonlinear fault-tolerant control (FTC) method based on Nussbaum gain technique is proposed for hypersonic vehicles with diverse faults.
Thus, the generation of the initial population is not random but a generation method based on diversification [ 36] is used to generate a set of diverse initial solutions.
Communication method based on competitiveness.
We developed a machine learning method based on the fusion of multiple kernels and support vector machines (SVMs) (Vapnik, 1995), a well-known machine learning method that has been widely used in diverse areas of bioinformatics.
Choose the method based on the objective.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com