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Diverse experimental protocols have demonstrated that the results of PCR-based methylation analyses are variable between experimental samples, and the analyses fluctuate according to the PCR conditions even with examining the same tissue DNA [ 39].
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However, a compilation of results across diverse taxa and experimental protocols will be inherently noisier and so less likely to find statistically significant relationships than a focused study of one species.
Historically, evidence of psychological measures and air ionization has been equivocal because research findings use heterogeneous experimental protocols evaluating diverse study populations; use various methods to measure mood-related outcomes; and use inadequate experimental design and procedures including control over relevant exposures [ 20].
All of these studies suffer from diverse limitations in design or reporting when compared to more recent experimental protocols and reports.
The resulting models are precise and surprisingly robust: a model for the identification of tRNA genes can be trained on human data with reads extracted under a specific experimental protocol (say Illumina GAII) and it can be used to reliably annotate expression profiles across diverse organisms (e.g. fly or plants), from data produced by different experimental protocols (see Section 3.2).
The Deakin University Animal Ethics Committee approved all experimental protocols.
Experimental protocols were approved by the Norwegian Animal Research Authority.
The Ethics Committee of Keio University approved all experimental protocols (approval in October 2012).
The experimental protocols were approved by the Animal Welfare Committee of Shandong University.
All experimental protocols were approved by the Rutgers Institutional Animal Care and Use Committee (IACUC).
Many experimental protocols require live cells rather than fixed.
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