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Because the Akt pathway plays vital roles in controlling many diverse essential cellular processes, it is likely that drugs would only be tolerated if they modestly inhibit the Akt-signalling network.
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It is now well established that prokaryotic cells assemble diverse proteins into dynamic cytoskeletal filaments that perform essential cellular functions.
Under photosynthetic growth conditions these metabolically diverse cells are very capable of directly synthesizing all essential cellular metabolites and likely not as reliant on chemotaxis.
It is also becoming clear that diverse molecular changes in cancers might actually be consistent in some essential cellular functions (hallmarks) whose alterations might collectively dictate malignant growth for almost all human cancers [ 23, 24].
It is possible that damage to the cell is caused not only by the shortage of essential cellular proteins but also by the advent of substantial amounts of diverse protein fragments.
Pyruvate is an essential cellular central metabolite in cyanobacteria, from which carbon flow was distributed to diverse derivates.
Published: November 20, 2014 The endosome-to-Golgi retrieval pathway is conserved across all eukaryotes, sorting a diverse set of cargo proteins that operate in lysosome biogenesis, iron homeostasis, polarity generation, and other essential cellular functions.
In general, basal autophagy plays a critical role in cellular homeostasis by degrading excessive and/or damaged organelles and proteins, thereby performing "in-house" quality control of essential cellular components., In addition to its basal function, autophagy can be induced by diverse stimuli such as nutrient deprivation, serum starvation, metabolic stress, radiation, and anticancer drugs.
Adenosine nucleotides provide energy for many essential cellular functions.
Mitochondria participate in a large number of essential cellular functions.
Why has transcription evolved into such an essential cellular process?
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