Sentence examples for diverse end points from inspiring English sources

Dose response studies using animals, tissues, and cells can examine diverse end points.

Two additional papers on multigenerational reproductive and prenatal developmental toxicity studies in ToxRefDB have been recently published (Knudsen et al. 2009; Martin et al. 2009b), again with the primary goal of providing diverse end points for predictive modeling as part of the ToxCast research program (Dix et al. 2007).

Using diverse end-points, our study shows that obesity is significantly associated with increased proteinuria in early stage patients, and the lean phenotype is linked with ESRD in all DN patients.

However, we are making progress in integrating data from diverse technologies and end points into what is effectively a systems-biology approach to toxicology.

The state of the science suggests that no single parameter, whether mass, size fraction, surface area, or a particular chemical component, is responsible for all the diverse mechanisms and toxicologic end points that have been associated with PM, and a more sophisticated approach to standards will be needed.

ToxCast and Tox21 contain several assays intended to evaluate chemicals' effects on steroid hormone signaling pathways, including a diverse group of ER end points (ERα and ERβ hetero- and homodimerization, binding, transcriptional activity, and proliferation in an estrogen-dependent breast cancer cell line) (Judson et al. 2010; Rotroff et al. 2013b; Sipes et al. 2013; Tice et al. 2013).

Similarly, poor correlation was found between in vitro cytotoxicity and in vivo rodent carcinogenicity, even when a diverse set of in vitro end points from HTS was used (Xia et al. 2008; Zhu et al. 2008).

However, existing modeling tools generally do not achieve good external accuracy of prediction for compounds not used in model development, and few QSAR models have been successful in predicting in vivo toxicity end points for diverse sets of environmental compounds (Benigni et al. 2007; Stouch et al. 2003).

Most studies were retrospective analyses, with a mix of diverse endometrial cancer stages, comparing dissimilar end points (e.g. number of lymph nodes per patient or per lymph node area, or per region of interest), using different treatment strategies, or performing lymphadenectomy to different levels of extent.

Conclusion: To resolve these and other issues, participants agreed that diverse scientific disciplines must coordinate to better understand the MOA leading to the various asbestos-related disease end points.

Although this list of health end points is culled from numerous sources with diverse criteria, the categories and end points show a general convergence that can shape priorities for the developing tracking network.