Sentence examples for diverse downstream effectors from inspiring English sources

As PI3K/AKT signaling has a pivotal role through regulating diverse downstream effectors, we sought to determine the potential downstream effector that involves in BKM120-induced apoptosis in MDR cells.

RhoGTPases control diverse downstream actions through distinct effector proteins.

This cytoplasmic signaling molecule mediates the effects of insulin, acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors, and mice lacking IRS2 have a diabetic phenotype.

To facilitate these diverse functions Rab27 interacts with eleven known downstream effectors (5, 13).

Their abilities are bound to numerous downstream effectors which lead to diverse parallel downstream signaling pathways [ 28].

Active GTP-bound Ras triggers multiple downstream effectors that lead to activation of diverse signaling cascades resulting in changes in cellular behavior.

Rac family members participate in various cellular events through their specific downstream effectors.

PAKs constitute a family of downstream effectors of small Rho GTPases Rac1 and Cdc42, which has diverse cellular functions by regulating cytoskeletal reorganization, cell survival and angiogenesis.

The active GTP-bound form of Rac proteins bind to specific downstream effectors and thereby participate in various cellular events.

This role of this pathway changes in response to diverse environmental cues and allows the upstream proteins that respond directly to extracellular signals (such as nutrient availability, energy status, and physical stresses) to communicate with downstream effectors which, in turn, regulate various essential cellular processes.

RAS and its downstream effectors have been targeted to develop therapeutic inhibitors in various cancers with frequently mutated KRAS or BRAF54,55,56.