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Investigation into the chemical constituents of plants of genus Hedysarum revealed diverse compounds, including flavonoids, triterpenes, coumarins, lignanoids, nitrogen compounds, sterols, carbohydrates, fatty compounds, benzofuran, and polysaccharides.
A SpectrumPlus (MicroSource) library representing 1920 structurally diverse compounds including known drugs, experimental actives, and pure natural products, was used.
An over-abundance of P-glycoprotein (P-gp), the protein product of the MDR1 gene [1], leads to multidrug resistance (MDR), because cancer cells become able to efflux a number of structurally diverse compounds including many chemotherapy agents, such as paclitaxel [11], [12], doxorubicin [13], and vinblastine [14].
LC-MS chromatogram indicated the composition of diverse compounds including flavonoids, phenolics and phytoestrogens.
These enzymes are involved in the production of a range of diverse compounds, including many clinically useful antibiotics.
Efflux pumps have been known to extrude structurally diverse compounds, including antibiotics and antiseptics used in a clinical setting [ 9].
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We examined how structurally and functionally diverse compounds included in the Tox21 chemical space modify core nuclear receptor functions of VDR with respect to VDR heterodimerization with human RXRα, recruitment of coactivator (SRC-1) or corepressor (NCoR), and the ability to initiate/inhibit transactivation of CYP24A1.
These structurally diverse compounds include abscisic acid, auxins, brassinosteroids, cytokinins (CTKs), GAs, ethylene, and jasmonates (JAs) [ 41].
Areca catechu contains diverse phenolic compounds, including condensed tannins, hydrolysed tannins, lignans, stilbenes, flavane, flavonoids (mainly catechin and epicatechin), anthocyanin, and simple phenolic acids.
Bacteria have evolved to metabolize diverse aromatic compounds including environmental pollutants, using these compounds as carbon and energy source.
Marine organisms contain structurally diverse bioactive compounds including many that are included in food and health care products.
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