Sentence examples for diverse compounds for from inspiring English sources

Thus, the fragment-based pharmacophore identified a small number of diverse compounds for assay, and greatly enhanced the selection process of advanced lead compounds for combinatorial design.

The application of the model shows great success in predicting the activities of 65 known 5-LO Xinhibitors in our test set with a correlation coefficient of 0.85 with a cross validation of 95% confidence level, proving that the model is reliable in identifying structurally diverse compounds for inhibitory activity against 5-LO X 5-LO X

Resent success in acquiring structurally diverse compounds for hit-to-lead optimization programs aiming at Chagas disease hinges on modern drug discovery strategies, including probing T. cruzi parasites or the CYP51 target in high-throughput format with diverse libraries of compounds, including those developed for different therapeutic applications.

These 3516 stereoisomers were docked into the chimeric α7/Ls-AChBP protein (PDB: 3SQ6) and after the post-processing step, the best-ranked 350 poses were visually inspected to yield a subset of 23 structurally new and diverse compounds for binding assays on the human α7 receptor (Figs. 4 and 6).

Natural product researchers have developed many new techniques over the past few years for developing diverse compounds of biopotential.

Of 16 diverse compounds selected for experimental screening, 2 prevented and reversed Aβ aggregation at 2 3 μM concentration, as measured by Thioflavin T (ThT) fluorescence and ELISA assays.

Modern synthetic organic chemistry allows for the preparation of virtually any molecule and more importantly, allows a cryobiologist to generate large chemical "libraries" of structurally diverse compounds suitable for the high throughput screening as cryoprotectants.

The acetamide structure of CLINME provides a unique opportunity to prepare structurally diverse compounds suitable for the incorporation of a variety of PET and SPECT isotopes.

The structurally diverse compounds were evaluated for elucidation of the BCRP polymorph mediated uptakes and establishment of the relationships with their molecular structures.

A library of 3,000 chemically diverse compounds was used for screening of 8226/Dox40 and parental RPMI 8226 cells at a concentration of 1 μg/ml, and cytotoxic/antiproliferative activity was determined using FMCA.

For compounds where we do not have experimental data, we make predictions of bioactivity, seeing a number of very interesting predictions of relevant pharmacological activities for diverse compounds.