Prolonged exposure of humans and experimental animals to the altered gravitational conditions of space flight has diverse effects on various cellular systems [34], [35], [36], [37], [38], [39].
Live DENV infection significantly regulated genes that are involved in diverse cellular physiological systems (Figure 1B).
Therefore, we conclude that the new network, YeastNet v. 2, is a significantly improved gene functional network, both showing higher accuracy and coverage, as well as better generalization to a more diverse set of cellular systems.
Of these, nucleases belonging to the classical HNH and NucA clades widely occur beyond the polymorphic toxins across diverse sub-cellular systems, such as, DNA repair/recombination, restriction-modification (R-M) and environmental nucleic acid degradation systems [ 103, 106, 111].
Estrogens are fundamental to the function of the female reproductive system, and have also been shown to regulate diverse cellular processes in the central nervous system, the cardiovascular system, and bone metabolism [ 1].
We show that TimeXNet is faster and more accurate at predicting active gene sub-networks than other existing tools in the study of cellular systems as diverse as the innate immune response in mouse and the yeast osmotic stress response.
Isoprenoids are a large and diverse group of natural compounds fulfilling a large number of diverse cellular functions in all biological systems, such as cell signaling processes, protein modifications (prenylation), synthesis of the co-factor ubiquinone and modifications of tRNAs, amongst others [11].
Osteopontin plays diverse cellular functions in innate immune system starting from promoting T helper cell type 1 (Th1) skewing and extended through the differentiation and proliferation of immune reactive cells [ 31, 36, 37].
We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.
