Sentence examples for diverse cellular effects from inspiring English sources

Connecting BMP activity to an SC's response to TGF-βs may explain why these signaling factors wield such diverse cellular effects.

Erythropoietin (EPO), the principal hematopoietic cytokine that regulates mammalian erythropoiesis, exhibits diverse cellular effects in non-hematopoietic tissues.

When activated, p53 can give rise to diverse cellular effects including cell cycle arrest, DNA repair or apoptosis, depending on which of its target genes are activated.

Signals from VEGF receptors drive diverse cellular effects in endothelial cells, including migration, proliferation, cell survival and the expression of downstream genes.

This complex then binds IFN-stimulated response elements (ISREs) inside DNA to initiate the transcription of hundreds of different ISGs, which are known to mediate the diverse cellular effects in the infected cell.

Members of the inhibitor of DNA binding family, which are dominant negative regulators of basic helix loop helix transcription factors with diverse cellular effects, are among the most important downstream targets and effectors of BMP signaling (Miyazono and Miyazawa 2002).

Altogether, this illustrates that EPLIN may be involved in the regulation of EMT and PCa progression and loss of EPLIN can lead to diverse downstream cellular effects.

Ubiquitin is a highly conserved 76 amino acid protein with diverse cellular functions effected by means of marking proteins for intracellular signalling [ 50].

Blocking GABA uptake or suppressing the expression of GAT-1 has diverse cellular and systemic effects [32], [33], possibly due to the overlapping effects of reduced GABA supply, enhanced tonic inhibition [31], [34] and prolonged duration of inhibitory postsynaptic potentials [29].

Beyond its well-documented role in ribosome and telomerase biogenesis, the DKC1 complex has been shown to effect diverse cellular processes including internal ribosome entry site (IRES -dependent translation (Yoon et al., 2006) and base excision of 5-hydroxymethyluridines in rRNA by uracil-DNA glycosylase 1 (SMUG1) (Jobert et al., 2013).

Therefore, HSP90 regulates diverse cellular functions and exerts marked effects on normal biology, disease and evolutionary processes.