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Geisler, S. & Coller, J. RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
Geisler S, Coller J. RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
We engineered a genetic toolset for flexible transgene regulation in these diverse cellular contexts.
However, implementing such complex networks requires well-characterized, orthogonally-acting biological parts that function consistently in diverse cellular contexts.
The Columbia University Department of Systems Biology had two research projects funded through LINCS, focusing on profiling signatures of synergistic chemical perturbations in diverse cellular contexts, and on using a systems approach to elucidate mechanisms of drug activity and sensitivity.
These data suggest that Dvl is a critical element for TGF β responsiveness in diverse cellular contexts.
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Because of its high target selectivity, nutlin represents an excellent tool for studying p53 regulation and function in diverse cellular context under well control conditions [ 22].
However, as this two-way interplay exhibits diverse characteristics and the activities are often combinatorial, depending upon various cellular contexts, extensive understanding of their roles in diverse aspects of cancer has a long way to go.
The identification of SCML2 as a PcG protein that binds RNA and contributes to repression of Polycomb targets will help shed new light on the interplay between ncRNAs and epigenetic regulation and on the combinatorial factors that drive the specificity of the diverse PcG complexes in different cellular contexts.
RNA editing especially has increased greatly during mammalian evolution and modulates diverse cellular functions presumably in a context-dependent manner.
TET proteins carry out RNA/DNA-processing activities in the context of diverse cellular functions.
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