The PI3K/Akt lipid kinase signaling pathway, which is involved in diverse cellular activities including glucose metabolism, was activated in melanoma cells.
Intriguingly, YeaG contains an amino-terminal ATPase Associated with diverse cellular Activities (AAA+) domain (Figure S1C).
Maintaining protein homoeostasis (proteostasis) is essential for diverse cellular activities in all life forms.
It is a member of the AAA + family (ATPases associated with diverse cellular activities).
The superfamily of ATPases associated with diverse cellular activities (AAA+) includes a wide variety of members that are involved in membrane fusion, DNA replication, protein degradation, and others1,2.
Dynein is a large cytoskeletal motor protein that belongs to the AAA + (ATPases associated with diverse cellular activities) superfamily.
The minichromosome maintenance (MCM) proteins, members of the AAA+ (ATPase associated with diverse cellular activities) superfamily, are believed to constitute the replicative helicase in eukaryotic and archaeal species.
The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases.
Cytoplasmic dynein, a member of the AAA ATPases Associatedd with diverse cellular Activities) family of proteins, drives the processive movement of numerous intracellular cargos towards the minus end of microtubules.
Meiotic clade AAA ATPases (ATPases associated with diverse cellular activities), which were initially grouped on the basis of phylogenetic classification of their AAA ATPase cassette, include four relatively well characterized family members, Vps4, spastin, katanin and fidgetin.
