Exact(2)
In contrast to the relatively non-specific methods mentioned above, numerous techniques have been developed for targeting and isolating single rare cancer cells from large populations of histologically diverse cells such as peripheral blood (Fig. 2).
Thus, critical information is lost when studying samples rich in specialized but diverse cells such as tumors, iPS colonies, or brain tissue.
Similar(58)
Accumulating data show that GA has a broad spectrum of antitumor activity against diverse tumor cells, such as human multiple myeloma U266 cells, human lung carcinoma SPC-A1 cells, and human hepatoma SMMC-7721 cells [21,22]. SMMC-7721 cells [21,22]
In addition, however, many non-neuronal cells are capable of ACh synthesis and release, including such diverse cell types such as keratinocytes, lymphocytes, placental trophoblast, endothelial cells and many more (for reviews, see Wessler et al. 1998, 2001b).
Other studies have demonstrated the benefits of HAM as a substrate for ex vivo expansion of diverse cell lines such as limbal epithelial, corneal and conjunctival epithelial cells (Grueterich et al. 2002; Pellegrini et al. 1997).
In particular, it was shown that nanotopography influences diverse cell behaviors such as cell adhesion, cytoskeletal organization, apoptosis, macrophage activation, and gene expression [1, 2], which in turn leads to proliferation, differentiation, and migration on various nanostructures including nanofibers [3], nanopillars [4], and nanogrooves [5, 6].
The immune system of our body contains diverse cell populations such as antigen presenting cells, natural killer cells, B and T lymphocytes.
Thus, VEGF probably exerts pleiotropic effects on diverse cell types such as RPE cells and monocytes, which play major roles in the development of PVR.
Par-6 and PKC-ζ (one of four atypical PKCs) belong to the Par3/Par-6/aPKC polarity complex that governs diverse cell functions such as localization of embryonic determinants and establishment of tissue and organ during the embryonal period and regulation of cell polarity and the asymmetric division of cells in mature organisms [41].
A growing body of evidence has suggested that PIP2, a phospholipid enriched at the plasma membrane, serves not only as a metabolic precursor of InsP3 [21], but also as a signaling molecule mediating diverse cell functions such as actin polymerization, regulation of ion channels, assembly and disassembly of vesicular coats, and mRNA processing [22] [26].
radiation, photodynamic therapy, and chemotherapeutic agents in diverse cell types such as lymphocytes, fibroblasts, endothelial cells, and tumor cells.
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