We and others have shown that COX-2 overexpression induces cell cycle arrest in diverse cells including chondrocytes, NIH 3T3 fibroblasts, human embryonic kidney 293 cells [9], [40].
Tumors that formed after cell injection contained not only tumor cells but diverse cells, including red blood cells, inflammatory cells, and stromal cells.
Diverse cells, including leukocytes, monocytes, and macrophages [ 4– 6], as well as other molecules, such as chemokines (monocyte chemoattractant protein-1) [ 7, 8], adhesion molecules (intercellular adhesion molecule-1 (ICAM-1)) [ 9, 10], are implicated in processes related to diabetic nephropathy.
In addition, the invasive front of breast cancer also includes infiltrates of diverse immune cells including macrophages, neutrophils, and mast cells, and displays angiogenesis, and desmoplasia with deposition of extracellular matrix (ECM), particularly collagen I [ 8].
Despite this similarity in molecular expression, these diverse chemoresponsive cells including SCCs and brush cells, are different in terms of function and therefore should not be considered to be a single cell type.
Solid tumor malignancies consist of a diverse population of cells, including tumor cells, fibroblasts, endothelial cells and immune cells [4], [5].
Polyamines have diverse roles within cells, including stabilization of phosphate charges on nucleic acids and other negatively charged polymers and scavenging of ROS [50].
Therefore, osteoblastic lineage cells comprise a diverse population of cells, including immature, differentiating, and mature matrix-producing osteoblasts.
In addition, nsLTPs are expressed in diverse organs and cells, including callus, germinating and maturing seeds, leaves, roots, stems, ovaries, anthers, and pollens [ 6, 14].
Diverse and specialized cells – including epithelial cells, fibroblasts, endothelial cells, inflammatory cells, and bone marrow derived progenitor cells – orchestrate this complex process in a temporally coordinated pattern to repair damaged tissue [ 3].
On binding to ECM, integrin 5α regulates diverse functions in tumor cells including migration, invasion, proliferation and survival through activation of various pathways such as MAPK.
