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This analysis was performed on the data set from [21], and then the resulting fitted/trained regression models were used to predict phenotypes in each of five separate and biologically diverse breast cancer data sets [25] [28].
Moreover, a clear difference in the expression level and activity of transcription factors has been demonstrated among diverse breast cancer cell lines [ 39].
Luminal A is proportionally the largest and most diverse breast cancer subtype and the greatest contributor to overall breast cancer mortality [ 22].
Therefore, in addition to ER protein expression, determination of ERE activity as an ER functional marker will be helpful for analysis of a variety of diverse breast cancer cases and the subsequent course of treatment.
In this large cohort of ethnically diverse breast cancer patients, high numbers of women used vitamin/mineral supplements in the 6 months following breast cancer diagnosis, often at high doses and in combination with other supplements.
Metformin is being investigated in vitro in different breast cancer cell types, reviewed below, and an understanding of the mode of action in diverse breast cancer cell types is providing some insights into drug resistance.
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Three genotypically diverse breast-derived cell lines were used for in vitro testing of the MNP.
Responses to growth factors are highly diverse across breast cancer cell lines, even within the same subtype.
Tissue array analysis was performed on 54 diverse human breast tissue samples with different histologic diagnoses (Table 1).
Specifically, ethnically diverse Jewish breast cancer individuals are significantly more likely to be R72 homozygotes, compared with average risk, unaffected individuals.
Such patient-derived models have also been demonstrated by others to faithfully maintain histology [ 57- 63], gene expression patterns [ 60- 63] and genomic features [ 57, 58, 61, 63, 64] in diverse human breast cancers, including triple-negative, ER positive and HER2-overexpressing tumors.
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CEO of Professional Science Editing for Scientists @ prosciediting.com