Instead, they represented a diverse array of hepatocyte-specific functional genes with significant over-representation of hepatocyte nuclear factor 4α (Hnf4a) binding sites in their promoters.
Finally, this study has broad implications for development and disease because CENP-F loss of function is likely to impact a diverse array of cell-specific activities.
Collectively, the nine reporter lines show that the X1 docking locus is amenable to the expression of a diverse array of promoter-specific patterns, without obvious leakiness in nontarget tissues other than that due to enhancers incorporated in the construct.
The preponderance of muscle related genes in the cervical thymus is unlikely to be due to the expression of a diverse array of tissue-specific genes in medullary thymic epithelial cells (mTECs) during negative selection [ 104] even though numerous tissue-specific antigens are known to be expressed in mTEC cells.
A particularly diverse array of 15 male-specific histone variants was uncovered, including a testes-specific H4t, the first metazoan H4 sequence variant reported.
Finally, this study has broad implications for development and disease because CENP-F loss of function affects a diverse array of cell-type-specific activities in other organs.
As an indication, various reports of diverse array of bioactive compounds from specific food residues and availability of highly sensitive measurement tools provide a great opportunity to quantify metabolites in different range of food waste materials.
We suspect that the gene products of the unique or more frequent alleles at this location are more effective at paralyzing a more diverse array of prey or are specific to prey that are uniquely only consumed at Easter Island.
Wnts are secreted glycoproteins that bind seven-transmembrane containing receptors Frizzleds, and stimulate diverse array of morphogenic and developmental-specific programs (Peifer and Polakis, 2000).
Similar to the more recent Entrez Gene [9], GeneLynx provided links to a diverse array of online resources with gene-specific information; these links were automatically compiled from numerous systems.
