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ABC transporter substrates include a diverse array of compounds, many of them structurally unrelated.
Macrophage activation and local tissue hypoxia are central components of the proposed mechanism of action that drives hemangiosarcoma in rodents exposed to a diverse array of compounds such as 2-butoxyethanol, peroxisome proliferator-activated receptor (PPAR) agonists and pregabalin [ 2].
A remarkably diverse array of compounds activate human PXR, although generally only at micromolar concentrations (less commonly at high nanomolar concentrations), consistent with a hypothesized function of PXR as a toxic compound sensor [ 3, 4] (see Figure 1 for chemical structures of some PXR activators).
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Given the low probability of any one chemical hit (series) being successfully progressed to a preclinical candidate, we sought chemically tractable compound scaffolds to allow the facile synthesis of diverse arrays of compounds to explore structure activity relationships (SAR), allowing rapid go/no go decisions on any particular series.
As an indication, various reports of diverse array of bioactive compounds from specific food residues and availability of highly sensitive measurement tools provide a great opportunity to quantify metabolites in different range of food waste materials.
The large number of CYPs in insect genomes has been suggested to be necessary to protect the insect from the diverse array of harmful compounds in its environment [14].
In addition, PPARα serves as receptor for a diverse array of synthetic compounds collectively referred to as peroxisome proliferators [ 17].
In addition, apricot and roseroot also possess a diverse array of bioactive compounds [ 6, 18- 20] which could be responsible for the elevated antioxidant properties of the phytococktail extracts.
It is interesting to note that the largest number of microsomal CBRs was found in the species A. nidulans, which is capable of colonising numerous environmental niches and therefore may require the ability to metabolise a more diverse array of xenobiotic compounds.
Glycomimetics are a diverse array of saccharide-inspired compounds, designed to mimic the bioactive functions of glycosaminoglycans.
The mammalian intestine also harbors a diverse array of microbial metabolite compounds that potentially modulate stem/progenitor cell activity.
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