This pattern recapitulates that observed in mutation accumulation studies [25], as would be expected for two strains that diverged in the laboratory.
Comparative similarity in mRNA pools was observed to rapidly diverge when the laboratory strains were compared to populations prior to and following the initiation of bradyzoite differentiation (Day-15 and pH-shifted populations).
In budding yeast, trans-acting regulators were linked to 365 of 570 (64%) genes whose expression diverged between a laboratory and a wild strain of Saccharomyces cerevisiae whereas only 36% of divergent gene expression was linked to individual cis-acting loci [ 27].
On the basis of the same biological sample and the same laboratory assay, companies may present diverging, and even contradictory, test outcomes over time.
This emphasizes the importance of testing with another method or repeating the test when clinical and laboratory analyses diverge.
As laboratory professionals diverge on the best method to estimate LRL, LRLs and their 95% CIs were estimated by three methods when appropriate: parametric, non-parametric bootstrap based on 500 bootstrap samples and non-parametric rank- based [ 24, 25, 41, 49].
Third, international comparison of norovirus strains is complicated because of their genetic diversity and the involvement of several laboratories in diagnosis; consequential different assays result in sequences with diverging lengths and from diverging genomic regions.
Comparing anti- Borrelia test results between laboratories and studies may be impossible if tests with widely diverging sensitivities and specificities are used [ 7].
Why this diverging picture?
