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Such discrepancies may be explained by diverging expression of RNA read-throughs in different cancer types, but also by the non-uniformity of the employed data filtering strategies.
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Although it is possible that all ESTs or cDNAs are not represented in the database, it may be that variation in expression reflects diverged expression of one of the homoeologous copies.
For ami-13.3, we observed diverging expression profiles at both time points of salt stress as compared with the empty-vector control.
We focused on the expression patterns of duplicated genes and found that whereas some duplicated genes retained their expression pattern, others have diverging expression patterns.
Thus, diverged temporal expression of paralogues seems to facilitate cellular orchestration under different periodic stimuli.
In that work, we focused our analysis on gene sets that showed monotonically diverging patterns of expression between CS and HM cultures.
Additionally, these genes show diverging patterns of expression, unequal rates of substitution and positive selection [ 6- 11].
Elahi, K. C. et al. Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns.
Interestingly, FXR unfolds diverging effects on the expression of different OATP family members.
Second, if the paralogs had diverged in expression pattern, with one of the paralogs losing expression in our sampled tissues sample (Singh and Hannenhalli 2008), then again the paralog pair would not be detected.
Overall, the GSEA results support the findings obtained with the K-means analysis, indicate that C and SR flies diverged profoundly in their expression of stress- and reproduction-related genes, and suggest the role of those gene classes in lifespan extension.
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