As pri- let-7 expression is dynamic during the L4 stage (A Pasquinelli, personal communication), we addressed the possibility that slightly divergent staging of the animals might account for this variability among the different trials.
Moreover, even if there is complete adaptive decoupling of divergent life stages, the transitional period between life stages is still likely to be a performance trough that exposes individuals to increased risks.
The divergent techniques of stage and film acting are well understood, and there are many leading players who excel in both.
By design, the use of the same ketone-derived enamine and a set of related complementary heterocyclic azadiene [4+2] cycloaddition reactions permitted the late stage divergent preparation of a series of alternative heterocyclic derivatives not readily accessible by more conventional approaches.
A recent genomic comparison of congeneric shallow and deep sea urchins indeed confirms that in particular genes expressed in the ecologically divergent life cycle stage show increased signatures of positive selection [ 15].
The discrepancy between the findings in different animals and diseases may also represent the fact that the role of each of these MMPs has been found to be divergent in different stages of disease progression [45].
Our interest in this Fe(III)/NaBH4-mediated reaction emerged not only from its use in accessing vinblastine but from the opportunity it presented for the late-stage, divergent preparation of otherwise inaccessible vinblastine analogues incorporating alternative C20′ functionality.
Helen Heineman explored the much-explored notion of the divergent worlds of the stage and the wings in "Replacements".
Divergent was an early stage investor in FlashSoft in April 2011.
The validation at this stage is divergent in nature and therefore inclusive and, as such, the guidelines might be over-inclusive.
Several factors may contribute to these divergent results, including developmental stage (embryonic vs. adult), tissue of origin (lung vs. skin), aging in vitro, transient overexpression of the protein, and/or interactions with the genetic background of distinct donors.
