Moreover, the magnitude of the evolutionary response during the divergent phase was smaller than during the convergent phase.
For a small number of individuals, HapMap and 1000 Genomes analyses yielded divergent phasing across the B-C region boundary.
The result from each run in the ancestral population phase was regarded as an initial allelic state in the divergent population phase.
In the ancestral population phase, a coalescent simulation program [29] for neutral models was used to create the initial state for the divergent population phase.
The divergent population phase was simulated with a forward-time simulation program for neutral or genic selection models, where the frequency of the advantageous allele was deterministically increased.
Since population size (N) and the number of SNPs (L) were restricted in the forward-time simulation due to the limitation of computational load, we set N = 1000 and L = 101 in the divergent population phase.
Following incorporation of the final Tyr building block, the peptide was further elongated to CCR5 2-22 CCR5 2-22he resin split into eight equal portions to facilitate divergent solid-phase manipulations at Tyr13, Tyr14, and the15.
In order to implement the proposed divergent solid-phase sulfation strategy, we first synthesized three preformed, orthogonally protected Tyr building blocks (10, 11, and 12), bearing side-chain o-Nb, All, and TBS protection of the phenolic Tyr side chain, respectively.
To estimate the detection power of rMHH and rHH, computer simulations were divided into two phases, divergent population phase and ancestral population phase (Fig. S1A).
For overlapping genes of type convergent and divergent the three phases are (123 321), (123:132), and (123:2123.
