Our findings, which mostly rely on intact scrambled comparisons across SF and exposure duration, thus cannot be due to divergent masking parameters.
As clearly documented in the work of Kim et al., we used the most stringent EPP value as our study was focused on "strict divergent gene analysis parameter" [ 65].
This "simple" model is potentially useful for large data sets with short (in this case, highly divergent) sequences when multiple parameter estimates are expected to have high associated variances [e.g., [ 57, 58]].
In addition to the variability of parameters due to divergent kinetics between clinical cases, there is a lesser amount parameter variability for each case, a.k.a., within case variability.
Previously, we reported that cytometry analysis of the local immune responses induced in mice dermally exposed to the respiratory sensitizer trimellitic anhydride (TMA 10%) and contact sensitizer dinitrochlorobenzene (DNCB 1%) could identify divergent expression of several immune parameters.
The indicated L2 residues were aligned with the MacVector software ClustalW algorithm using the BLOSUM series matrix with default settings for open gap penalty, extended gap penalty, delay divergent percentage, and protein gap parameters.
Estimates of these demographic parameters in ecologically divergent lineages provide important insights into evolutionary histories, population dynamics, and the maintenance of adaptive divergence.
However, the standard approaches and the FI decoding algorithm provided clearly divergent estimates of the tuning parameters of the neuronal population that could underlie the psychophysically observed effect.
All web-based queries used the blastn algorithm parameters adjusted for divergent sequences (discontinuous blastn) [ 57], and database search results were filtered as described by Coates et al. [ 13].
