Interestingly, the higher percentage of reciprocal expression found among the tandem duplicates in the ADA data set is partly due to the more divergent organ types, suggesting that expression patterns among the tandem duplicates may diverge more across different organ types than the WG duplicates when compared with the ARA data set.
While it is unreasonable to expect that genetic regulatory networks controlling the development of organs in highly divergent organisms will be conserved in their entirety, application of the approach proposed here to identify conserved network modules should allow systems biologists to better capitalize on what is known in one species to advance discovery in another.
Several studies indicate that the genetic architecture of gene expression is highly divergent between organs and/or developmental stages which will be reflected in eQTL tissue specificity [ 5, 19- 21].
Although simultaneously hermaphroditic land snails with internal fertilization have divergent reproductive organs [ 58, 59], even within the same species [ 57, 60], the effects of these differences in genitalia have been overlooked in the context of strategic ejaculation in land snails [ 32, 33, 61].
To explore potential divergent effects on different organ systems, both adjusted and unadjusted analyses were repeated separately for each individual item of the infectious score.
Moreover, we should reconsider whether RA should be viewed as the disease that Garrod described or whether it represents a final common pathway of divergent mechanisms in an organ (synovium) with a limited repertoire of responses.
The four other prospective studies in the field of solid organ transplantation showed divergent results.
Various types of additional apical plate cells would then have subsequently been recruited to form part of the apical organ in the divergent bilaterian lineages.
Various types of apical plate cells would then have subsequently been added to the apical organ in the divergent bilaterian lineages.
Although these tumors arise in organs that are widely divergent in terms of anatomic localization, structure and physiological function, both organs require gonadal hormones for normal development.
