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Combining molecular analyses with in vitro and in vivo functional assays, we demonstrated that CD127− and CD127+ ELPs emerged independently from lympho-mono-dendritic progenitors, responded differently to Notch1 signals, underwent divergent modes of lineage restriction, and displayed both common and specific differentiation potentials.
Divergent modes of activation of human DC have been reported for TLR2 and TLR4 ligands (30).
Such variation precludes any firm conclusions but could reflect the involvement of different genes in bats that have evolved divergent modes of echolocation.
The complex pathophysiology underlying the metabolic syndrome requires the combination of different agents with divergent modes of action, as discussed above.
The possibility that divergent modes of PGC specification could exist within an individual phylum, such as amphibians, was difficult to reconcile amidst prevailing knowledge of the time.
These results demonstrate that divergent modes of αSynuclein neurotoxicity exist in invertebrate and mammalian DA neurons in vivo and suggest that fibrillation of αSynuclein promotes the progressive degeneration of nigral DA neurons as found in PD patients.
Similar(53)
A weighting matrix with finite weights is applied for the control of complex modes, whereas a weighting matrix with an infinite weight is used for controlling the divergent mode, with roots being real.
KAR, SSE, SSZ, and LHS subfamilies evolved in a simple divergent mode with little copy number dynamics.
The divergent mode allows a given uni- or multisensory information to be sent simultaneously to remote sensory and/or motor cortical areas (Fig. 3 G ).
Also indicative of a divergent mode of sequence evolution controlled by purifying selection, the tree topology for singleton SSB genes was consistent with the species tree (fig. 1; supplementary fig. S2, Supplementary Material online).
However, the amino acid phylogeny of paralogous SSB1/SSB2 sequences from post-WGD Saccharomycetaceae species show a complex branching pattern not consistent with a divergent mode of sequence evolution (supplementary fig. S2 A, Supplementary Material online).
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