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By tracking the gene expression changes en route to these cell fates, we found a subset of the differentially expressed genes that exhibited a divergent gene expression pattern, hypothesized to correspond to the observed macroscopic cell type phenotype.
Our results showing that highly expressed genes are associated with slow-evolving protein sequences and less divergent gene expression patterns may suggest that the correlation between protein divergence and expression divergence is a result of between-gene variation in expression levels.
Moreover, the paired action of PTCs and nonsense-mediated decay has been suggested as a novel mechanism to regulate gene expression [ 21- 24] and the observed frequent occurrence of PTC mutations further support the hypothesis that divergent gene expression and alternative splicing affect the phenotypic divergence.
Based on the gene expression data, immune cells from the FGT and peripheral blood show divergent gene expression patterns.
In a number of species, recent work has associated gene duplication with divergent gene expression patterns in response to developmental or abiotic stress cues [8] [12].
The specialization has been afforded through differential subcellular localization of the encoded products and divergent gene expression patterns, which is reflected in enzyme activity under various physiological conditions.
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Furthermore, by integrating these two data sets we assessed divergent gene-expression profiles between the myocardial and Epi lineages and found a central role for Wnt signaling to be associated with the "epicardial lock".
In some cases, NvNRs supported as likely lineage specific duplications showed divergent temporal gene expression patterns consistent with subfunctionalization.
They reported that isogenic Sca-1high and Sca-1low cells, despite both being multipotent, had divergent global gene expression profiles and were functionally different.
We tested whether there was any significant difference in rates of molecular evolution between the dendritic expression divergent genes (from expression comparison described above) and non-divergent genes.
A differential clustering algorithm revealed similar and divergent gene co-expression patterns among the two genotypes.
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